Synopsis:
This study investigated the protective effects of caffeic acid phenethyl ester (CAPE) against rifampicin-isoniazid induced hepatic and pancreatic toxicity in terms of histopathological deterioration, oxidative stress (paraoxonase-1, total antioxidant status, Total oxidant status) and biochemical parameters changes. The side effects of INH and RFP treatment on hepatic and pancreatic tissues may be prevented with CAPE.