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B Vogler

The in vitro Anti-denaturation Effects Induced by Natural Products and Non-steroidal Compounds in Heat Treated (Immunogenic) Bovine Serum Albumin is Proposed as a Screening Assay for the Detection of Anti-inflammatory Compounds, without the use of Animals

Issue: 
Pages: 
327–31
Synopsis: 
Heat treated (immunogenic) Bone Serum Albumin is hereby proposed as an assay for the detection of selected therapeutic drugs.

ABSTRACT

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e-Published: 23 Jul, 2013

In Vitro Anti-Proliferation/Cytotoxic Activity of Epingaione and its Derivatives on the Human SHSY5Y Neuroblastoma and TE-671 Sarcoma cells

Issue: 
Pages: 
5–10
Synopsis: 
The present article evaluates the in vitro antiproliferation/ cytotoxic activity of Epingaione and selected derivatives isolated from Bontia daphnoides L on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells.

ABSTRACTS

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e-Published: 01 Jul, 2013

In Vitro Anti-Proliferation/Cytotoxic Activity of Epingaione and its Derivatives on the Human SHSY5Y Neuroblastoma and TE-671 Sarcoma cells

Epingaione (4-Methyl-1-(5-methyl-2,3,4,5-tetrahydro-[2,3’]bifuranyl-5-yl)-pentan-2-one) was isolated as one of the major lipophilic secondary metabolites from the leaves and stems of Bontia daphnoides L. The compound gave 79.24% and 50.83% anti-proliferation/cytotoxic activity on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells in vitro at 50 μg/mL, respectively. Epingaione was transformed into eleven derivatives under laboratory conditions using ethanol, some gave greater anti-proliferation/cytotoxic activity on the cancer cell lines tested.

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e-Published: 01 Jul, 2013

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