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Neuroblastoma cell

In Vitro Anti-Proliferation/Cytotoxic Activity of Epingaione and its Derivatives on the Human SHSY5Y Neuroblastoma and TE-671 Sarcoma cells

Issue: 
Pages: 
5–10
Synopsis: 
The present article evaluates the in vitro antiproliferation/ cytotoxic activity of Epingaione and selected derivatives isolated from Bontia daphnoides L on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells.

ABSTRACTS

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e-Published: 01 Jul, 2013

In Vitro Anti-Proliferation/Cytotoxic Activity of Epingaione and its Derivatives on the Human SHSY5Y Neuroblastoma and TE-671 Sarcoma cells

Epingaione (4-Methyl-1-(5-methyl-2,3,4,5-tetrahydro-[2,3’]bifuranyl-5-yl)-pentan-2-one) was isolated as one of the major lipophilic secondary metabolites from the leaves and stems of Bontia daphnoides L. The compound gave 79.24% and 50.83% anti-proliferation/cytotoxic activity on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells in vitro at 50 μg/mL, respectively. Epingaione was transformed into eleven derivatives under laboratory conditions using ethanol, some gave greater anti-proliferation/cytotoxic activity on the cancer cell lines tested.

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Journal Sections: 
e-Published: 01 Jul, 2013

Pre-published Manuscript

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In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

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