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D Wheatle

Antihistamine Effect of a Pure Bioactive Compound Isolated from Slug (Diplosolenodes occidentalis) Material

Issue: 
DOI: 
10.7727/wimj.2013.269
Pages: 
401–7
Synopsis: 
In Jamaica, the slug, (Diplosolenodes occidentalis) is used in folklore practice to alleviate the symptoms of an asthmatic attack. A pure bioactive compound, glyceryl trilinolenate (GT) was isolated from the crude slug extract. Glyceryl trilinolenate is a non-toxic and specific H1 antagonist acting non-competitively to produce relaxation of tracheal smooth muscle. It also reduces cutaneous wheal formation and inflammation. This is the first scientific documentation of the actions of GT.

ABSTRACT

Objective: Folklore claims of the therapeutic effect of garden slug (Diplosolenodes occidentalis) extract used to relieve bronchoconstriction in asthmatic individuals were never validated scientifically. The aim of this study was to isolate the pure bioactive compound from slug extract causing this effect.

Accepted: 
24 Feb, 2014
PDF Attachment: 
Journal Sections: 
e-Published: 03 Jul, 2014
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