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OR Simon

Antihistamine Effect of a Pure Bioactive Compound Isolated from Slug (Diplosolenodes occidentalis) Material

Issue: 
DOI: 
10.7727/wimj.2013.269
Pages: 
401–7
Synopsis: 
In Jamaica, the slug, (Diplosolenodes occidentalis) is used in folklore practice to alleviate the symptoms of an asthmatic attack. A pure bioactive compound, glyceryl trilinolenate (GT) was isolated from the crude slug extract. Glyceryl trilinolenate is a non-toxic and specific H1 antagonist acting non-competitively to produce relaxation of tracheal smooth muscle. It also reduces cutaneous wheal formation and inflammation. This is the first scientific documentation of the actions of GT.

ABSTRACT

Objective: Folklore claims of the therapeutic effect of garden slug (Diplosolenodes occidentalis) extract used to relieve bronchoconstriction in asthmatic individuals were never validated scientifically. The aim of this study was to isolate the pure bioactive compound from slug extract causing this effect.

Accepted: 
24 Feb, 2014
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e-Published: 03 Jul, 2014

Six-shogaol inhibits Production of Tumour Necrosis Factor Alpha, Interleukin-1 beta and Nitric Oxide from Lipopolysaccharide-stimulated RAW 264.7 Macrophages

Issue: 
Pages: 
295–300
Synopsis: 
Six-shogaol is a major constituent of the rhizome from the ginger plant. In this study, evidence that 6-shogaol significantly inhibited production of pro-inflammatory cytokines TNF-alpha, IL-1 beta and nitric oxide from lipopolysaccharide stimulated RAW 264.7 macrophages was obtained. Such inhibition might explain the anti-inflammatory mechanisms and the therapeutic potential of this ginger compound.

ABSTRACT

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e-Published: 19 Sep, 2013

REVIEW ARTICLE: The Past and Present Use of Plants for Medicines

Issue: 

INTRODUCTION

In early civilizations, illness was usually believed to be due to divine punishment. The Aztecs Indian of South America, for example, believed that particular diseases were linked to specific gods; thus their god Tlaloc was associated with diseases caused by water, such as oedema (4). Similarly, Greek physicians, such as Theoprastus, were generally followers of Asclepius, the god of Medicine. Thus the use of plants for healing became strongly associated with the gods.

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e-Published: 10 Jun, 2013

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

The Effect of Phytic Acid on the Levels of Blood Glucose and Some Enzymes of Carbohydrate and Lipid Metabolism

Issue: 
Pages: 
102–6
Synopsis: 
The changes in some of the hepatic metabolic enzymes in rats fed phytic acid extract from sweet potato are geared towards compensating for the decreased glycolytic responses.

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e-Published: 05 Jun, 2013
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