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AS Jacob

Investigation of the Anti-inflammatory and Analgesic Effects of the Aqueous Extract Obtained from the Bark of Guiacum Officinale (Lignum Vitae)

Issue: 
DOI: 
10.7727/wimj.2015.089
Pages: 
593–97
Synopsis: 
The bark of Guiacum Officinale (Lignum Vitae) is commonly used in folklore practice in Jamaica as a tea preparation to reduce inflammation and pain in knee joints. This study investigated and validated these claims and confirms no toxic effects within 24 hours at the doses used.

 ABSTRACT

Accepted: 
26 Mar, 2015
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Journal Sections: 
Journal Authors: 
e-Published: 04 Nov, 2015

Preliminary Investigations of the Anti-asthmatic Properties of the Aqueous Extract of Justicia pectoralis (Fresh Cut)

Issue: 
DOI: 
10.7727/wimj.2014.149
Pages: 
320–4
Synopsis: 
Justicia pectoralis is commonly used in Jamaica as a tea preparation to alleviate the difficulty in breathing in asthmatic individuals. This study investigated its effects on tracheal contraction and allergic wheals in the dermis.

ABSTRACT

Accepted: 
30 Jun, 2014
PDF Attachment: 
Journal Sections: 
e-Published: 04 May, 2015

Antihistamine Effect of a Pure Bioactive Compound Isolated from Slug (Diplosolenodes occidentalis) Material

Issue: 
DOI: 
10.7727/wimj.2013.269
Pages: 
401–7
Synopsis: 
In Jamaica, the slug, (Diplosolenodes occidentalis) is used in folklore practice to alleviate the symptoms of an asthmatic attack. A pure bioactive compound, glyceryl trilinolenate (GT) was isolated from the crude slug extract. Glyceryl trilinolenate is a non-toxic and specific H1 antagonist acting non-competitively to produce relaxation of tracheal smooth muscle. It also reduces cutaneous wheal formation and inflammation. This is the first scientific documentation of the actions of GT.

ABSTRACT

Objective: Folklore claims of the therapeutic effect of garden slug (Diplosolenodes occidentalis) extract used to relieve bronchoconstriction in asthmatic individuals were never validated scientifically. The aim of this study was to isolate the pure bioactive compound from slug extract causing this effect.

Accepted: 
24 Feb, 2014
PDF Attachment: 
Journal Sections: 
e-Published: 03 Jul, 2014
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