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Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels Streptozotocin Induced Diabetic Rats

DOI: 
10.7727/wimj.2016.106
Synopsis: 
Leptin and Endothelin (ET) as important endogenous factors interact with each other which may contribute to a better understanding their role in diabetic pathogenesis. We aimed to evaluate the relationship between Leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on Leptin levels in rats with diabetes induced by Streptozotocin (STZ). In this study, 24 male Wistar-albino rats were divided into three groups; Control, STZ, STZ + BQ-123 relatively reduced oxidative stress and Leptin levels. ETaR ANTAGONIST bq-123 has positive impacts depending on the dosage in the diabetic rats.

ABSTRACT

 

Objectives: Leptin and Endothelin (ET) as important endogenous factors interact with each other which may contribute to a better understanding their role in diabetic pathogenesis.

We aimed to evaluate the relationship between Leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on Leptin levels in rats with diabetes induced by Streptozotocin (STZ).

Accepted: 
25 May, 2016
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Journal Sections: 
e-Published: 07 Jul, 2016

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Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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