Beta-thalassaemia major patients require monthly blood transfusions. Studies on the oxidant-antioxidant indices in patients on desferrioxamine-chelation or without chelation indicate that desferrioxamine chelation does not normalize ferritin level but attenuates oxidative damage and improves total antioxidant level in these patients.
Keratoconic patients have reduced paraoxonase activity,
which suggests that keratoconic corneas are more
susceptible to oxidative stress. Reduced paraoxonase
activity and keratoconus status appear to be associated