R Kaomongkolgit

Porphyromonas gingivalis LPS-induced IL-1β and IL-8 Expression by Reducing MAPK Activation in THP-1 Cells

DOI:

10.7727/wimj.2016.081

Synopsis:

The study investigated the inhibitory effects of alpha-mangostin on Porphyromonas gingivalis lipopolysaccharide (LPS)-induced production of pro-inflammatory cytokines and activation of mitogen-activated protein kinase (MAPK) signaling in THP-1 cells. The results indicated that alpha-mangostin suppresses the production of IL-1β and IL-8 in P. gingivalis LPS-stimulated THP-1 cells, possibly by reduction the activation of MAPK pathway. These findings suggest the possible use of alpha-mangostin as an anti-inflammatory agent in adjunctive treatment of periodontitis.

ABSTRACT

Objective:To investigate the inhibitory effects of alpha-mangostin on Porphyromonas gingivalis lipopolysaccharide (LPS)-induced production of pro-inflammatory cytokines and activation of mitogen-activated protein kinase (MAPK) signaling in THP-1 cells.

Received:

29 Feb, 2016

Accepted:

31 Mar, 2016

PDF Attachment:

yiemwattana_et_al-suppression_of_il-1v_and_il-8_expression_in_thp-1.pdf

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e-Published: 05 Apr, 2016

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