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Porphyromonas gingivalis LPS-induced IL-1β and IL-8 Expression by Reducing MAPK Activation in THP-1 Cells

DOI: 
10.7727/wimj.2016.081
Synopsis: 
The study investigated the inhibitory effects of alpha-mangostin on Porphyromonas gingivalis lipopolysaccharide (LPS)-induced production of pro-inflammatory cytokines and activation of mitogen-activated protein kinase (MAPK) signaling in THP-1 cells. The results indicated that alpha-mangostin suppresses the production of IL-1β and IL-8 in P. gingivalis LPS-stimulated THP-1 cells, possibly by reduction the activation of MAPK pathway. These findings suggest the possible use of alpha-mangostin as an anti-inflammatory agent in adjunctive treatment of periodontitis.

ABSTRACT

Objective:To investigate the inhibitory effects of alpha-mangostin on Porphyromonas gingivalis lipopolysaccharide (LPS)-induced production of pro-inflammatory cytokines and activation of mitogen-activated protein kinase (MAPK) signaling in THP-1 cells.

Accepted: 
31 Mar, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 05 Apr, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Severe Antiepileptic Drug-induced Gingival Overgrowth in a Physically Disabled Patient

Issue: 
DOI: 
10.7727/wimj.2014.359
Pages: 
212–5

ABSTRACT

Accepted: 
12 Dec, 2014
PDF Attachment: 
Journal Sections: 
e-Published: 08 May, 2015
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