Pakistan in recent times, is placed in the 5th place among high TB prevalent countries, world wide. Cases of extended TB resistance have also been reported in Pakistan, whereas TB resistance cases are common. Given the country's cultural constraints, it is speculated that there are gender differences in TB prevalence and treatment outcomes. The current study provides the data for the risk factors that affect the development of TB based on gender and evaluates the treatment outcomes. Evaluating the past practices and identifying the risk factors, can provide us important information for future directions to control and treat TB in a high TB prevalent country such as Pakistan.