Asthma

The Efficacy of H89 on Aquaporin 5 Levels in Asthmatic Rat Models

Issue:

Vol 71, Issue 1: 2024

DOI:

10.7727.wimj/2016.313

Pages:

37-41

Synopsis:

Asthma is a disease that progresses depending on the increased sensitivity in the respiratory tract and hypersecretion by goblet cells in bronchia. Inflammation sources that play a role in asthma’s physiopathology are T lymphocytes, mast cells, eosinophils, and macrophages. Biopsy studies have revealed that there are correlations between density of inflammation and intensity of the diseases The effect of specific protein kinase A inhibitor H89 treatment reduced Aq 5 receptor expressions on the lung tissue.

ABSTRACT

Background: The effect of a specific protein kinase A inhibitor H89 on Aquaporin 5 (AQ5) levels, which has a role in the inflammation of asthma pathogenesis, was investigated in this study.

Objective: To prove that H89, which was thought to be a promising agent, may show antiinflammatory activity in the treatment of asthma by causing inhibition of the protein kinase A enzyme that is involved in inflammation.

Received:

27 Jun, 2016

Accepted:

16 Aug, 2016

Published:

30 Mar, 2024

PDF Attachment:

wimj-iss1-2024_37_41.pdf

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e-Published: 22 Aug, 2016

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Children, Asthma and Emergency Rooms: A Retrospective Review of Hospital Records in Nevis, West Indies

DOI:

10.7727/wimj.2016.241

Synopsis:

Asthma has replaced gastroenteritis as the most frequent diagnosis in Kittitian and Nevisian children. The purpose of this randomized chart review was to identify pediatric emergency room (ER) utilization patterns at Alexandra Hospital, WI for asthma treatment. This analysis would inform the pediatric asthma-related burden to the Alexandra Hospital ER and the Nevis health system. This study revealed a greater utilization of ER services among particular pediatric subpopulations for the treatment of asthma.

ABSTRACT

Objectives: We sought to identify pediatric emergency room (ER) utilization at Alexandra Hospital Nevis, WI for asthma.

Received:

01 Jun, 2016

Accepted:

30 Jun, 2016

PDF Attachment:

jones20et20al-pediatric20asthma20surveillance20at20the20alexandra20hospital20er20in20nevis20wi1.pdf

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Keywords:

public health surveillance

Journal Authors:

E Jones

J Richardson

e-Published: 21 Jul, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Metered-dose Inhaler Technique and Asthma Control in Patients Attending an Urgent Care Clinic in Barbados

Issue:

Vol 66, Issue 6: 2017

DOI:

10.7727/wimj.2015.584

Pages:

723–28

Synopsis:

Sixty-three per cent of asthmatics attending an urgent care clinic in Barbados had controlled asthma, and 16% were attending for asthma treatment. Ninety-seven per cent felt that their metered-dose inhaler technique was correct, but only 5% had correct technique.

ABSTRACT

Objective: To estimate the proportion of asthmatics with correct pressurised metered-dose inhaler (MDI) technique.

Methods: All asthmatics 12 to 65 years of age using a MDI and attending an urgent care clinic on selected clinic days over a five-month period were administered a questionnaire and had their MDI technique evaluated.

Received:

03 Dec, 2015

Accepted:

07 Dec, 2015

Published:

29 Dec, 2017

PDF Attachment:

wimj-iss-6-2017_723_728.pdf

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e-Published: 29 Mar, 2016

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A Standardized versus an Individualized Approach in Managing Difficult Asthma: A Dilemma

DOI:

10.7727/wimj.2015.219

Synopsis:

The current case study presents a case of uncontrolled asthma. Spirometery forms one of the important parameters in assessing lung function assessment. Despite the normal values of spirometery, patient clinical presentation did not related to her spirometry values. After troubling four years, doctors initiated Anti-IgE monoclonal antibody therapy that resulted in the patient's improvement. Often, during clinical practices doctors face challenges where they have to make patient decisions based on their clinical expertise rather than following the standard protocols

ABSTRACT

Background: The adherence to clinical practice guidelines often aids in improving clinical decisions. However, doctors at times have to look beyond clinical practice guidelines to treat their patients. Situational awareness and clinical experience often put doctors in a better position to treat and manage asthmatic patients.

Received:

04 May, 2015

Accepted:

18 Mar, 2015

PDF Attachment:

aftab20et20al-approach20in20managing20difficult20asthma1.pdf

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e-Published: 12 Nov, 2015

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Impaired Bronchoprotection Is Not Induced by Increased Smooth Muscle Mass in Chronic Treatment In Vivo with Formoterol in Asthmatic Mouse Model

Issue:

Vol 63, Issue 6: Oct (2014)

DOI:

10.7727/wimjopen.2014.177

Pages:

641–6

Synopsis:

Compelling evidence proves that bronchial smooth muscle mass significantly increases in asthmatics, and chronic formoterol administration induces impaired bronchoprotection. No significant difference was detected in increased smooth muscle mass, implying that some other molecular mechanisms might be involved.

ABSTRACT

Received:

24 Jul, 2014

Accepted:

11 Aug, 2014

PDF Attachment:

luo_et_al-impaired_bronchoprotection_and_increased_smooth_muscle_mass.pdf

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e-Published: 16 Jan, 2015

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Exploration of the Genetic Epidemiology of Asthma: A Review, with a Focus on Prevalence in Children and Adolescents in the Caribbean

Issue:

Vol 63, Issue 7: Dec (2014)

DOI:

10.7727/wimj.2014.115

Pages:

687–92

Synopsis:

The authors address and review the literature and findings regarding the epidemiology and genetic factors involved in the pathogenesis of asthma, with an included focus on the epidemiology and prevalence of this debilitating condition in the child and adolescent Caribbean population.

ABSTRACT

Received:

19 May, 2014

Revised:

05 Sep, 2014

Accepted:

05 Jun, 2014

PDF Attachment:

wimjdec2014_687_692.pdf

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e-Published: 03 Sep, 2014

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The Prevalence of Asthma in an Adult Population in Khorramabad, Iran

Issue:

Vol 63, Issue 5: Sep (2014)

DOI:

10.7727/wimj.2013.136

Pages:

443–6

Synopsis:

This study has aimed to evaluate the prevalence of asthma in Khorramabad. The prevalence of asthma in Khorramabad in our study was more than in other similar studies in Iran and other countries. Doing analytical studies on the prevalence of asthma and its risk factors is recommended.

ABSTRACT

Objective: Asthma is one of the most common respiratory disorders. There have not been any studies assessing the prevalence rate for asthma based on spirometry in an adult population in the west of Iran. The aim of this study was to assess the prevalence of asthma in an adult population in Khorramabad, in the west of Iran.

Received:

07 May, 2013

Accepted:

27 Aug, 2013

PDF Attachment:

amiri_et_al-prevalence_of_asthma_in_adults.pdf

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e-Published: 08 May, 2014

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Is Free Running Asthma Screening Test Still Useful?

Issue:

Vol 59, issue 3 (2010)

Pages:

287–90

Synopsis:

Exercise-induced bronchospasm and asthma are often undiagnosed. Three per cent of the children that concluded a Free-Running-Asthma-Screening-Test were newly diagnosed cases of asthma. The outcome of the challenge was much more useful than a questionnaire on asthma symptoms.

ABSTRACT

Objective: The aim of this study is to evaluate the usefulness of Free Running Asthma Screening Test (FRAST) as a method that may help the diagnosis of exercise-induced bronchospasm (EIB) in children from a rural area and to compare the results with their history of asthma.

PDF Attachment:

dr_pitsios.qxd_.pdf

Journal Sections:

Original Articles

Keywords:

Asthma

exercise-induced brochospasm

exercise-induced asthma

Journal Authors:

C Pitsios

SR Del Giacco

C Grigoreas

e-Published: 07 Oct, 2013

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The Incidence of Asthmatic Attacks in Barbados

Issue:

Vol 56, Issue 5 (2007)

Pages:

427–32

Synopsis:

The demographic analysis of asthmatic cases found higher attack rates in males than in females, higher number of attacks in children less than five years old and exponential decrease attack rates with age. The highest correlation with the meteorological variables was with the vapour pressure.

ABSTRACT

PDF Attachment:

depradine_the_incidence_of_asthmatic_attacks_in_barbados.pdf

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e-Published: 03 Jul, 2013

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Skin Test Reactivity to Aeroallergens in Jamaicans: Relationship to Asthma

Issue:

Vol 55, Issue 3 (2006)

Pages:

142–7

Synopsis:

Although skin prick test reactivity to house dust mite is more common in Jamaican adults and children, it is reactivity to cockroach which is significantly associated with asthma in adults.

ABSTRACT

Background: Asthma causes significant morbidity and mortality in the developing world. It is thus important to identify modifiable risk factors.

Objectives: To undertake a cross-sectional study to determine the prevalence of skin test reactivity to aeroallergens in Jamaican children and adults and the relationship of the diagnosis of asthma to the pattern of skin test positivity.

PDF Attachment:

knight-madden_skin_test_reactivity.pdf

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