Administration

Different Doses and Routes of Administration of Methimazole Affect Thyroid Status in Methimazole-induced Hypothyroidism in Rats

Issue:

Vol 65, Issue 1: 2016

DOI:

10.7727/wimj.2014.241

Pages:

93–7

Synopsis:

In the present study, we established and compared differences of the rat’s hypothyroid model induced by MMI added to drinking water or given through an intragastric tube.

ABSTRACT

Objective: It is agreed that methimazole (MMI) can be administered to induce hypothyroidism. However, there are conflicting data about its effect on thyroid function and development in rats through different administrations. In the present study, we established and compared differences of the rat hypothyroid model induced by MMI added to drinking water or given through an intragastric tube.

Received:

06 Oct, 2014

Accepted:

31 Oct, 2014

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