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Aquaporin 5

The Efficacy of H89 on Aquaporin 5 levels in Asthmatic Rat Models

Asthma is a disease that progresses depending on the increased sensitivity in the respiratory tract and hypersecretion by goblet cells in bronchia. Inflammation sources that play a role in asthma’s physiopathology are T lymphocytes, mast cells, eosinophils, and macrophages. Biopsy studies have revealed that there are correlations between density of inflammation and intensity of the diseases The effect of specific protein kinase A inhibitor H89 treatment reduced Aq 5 receptor expressions on the lung tissue.


Objective: The effect of specific protein kinase A inhibitor H89 on Aquaporin 5 levels, which has a role in the inflammation of asthma pathogenesis, was investigated in this study.

16 Aug, 2016
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e-Published: 22 Aug, 2016


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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