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protein kinase A

The Efficacy of H89 on Aquaporin 5 Levels in Asthmatic Rat Models

Asthma is a disease that progresses depending on the increased sensitivity in the respiratory tract and hypersecretion by goblet cells in bronchia. Inflammation sources that play a role in asthma’s physiopathology are T lymphocytes, mast cells, eosinophils, and macrophages. Biopsy studies have revealed that there are correlations between density of inflammation and intensity of the diseases The effect of specific protein kinase A inhibitor H89 treatment reduced Aq 5 receptor expressions on the lung tissue.


Background: The effect of a specific protein kinase A inhibitor H89 on Aquaporin 5 (AQ5) levels, which has a role in the inflammation of asthma pathogenesis, was investigated in this study.

Objective: To prove that H89, which was thought to be a promising agent, may show antiinflammatory activity in the treatment of asthma by causing inhibition of the protein kinase A enzyme that is involved in inflammation.

16 Aug, 2016
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e-Published: 22 Aug, 2016
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