Close Menu

Books in a Library

Caspase 8

Cassia alata Leaf Extract Induces Cytotoxicity in A549 Lung Cancer Cells via a Mechanism that is Caspase 8 Dependent

The cytotoxic effect of a hexane extract of Cassia alata (C alata) leaves in parental and Caspase 8, 3 and 9 negative A549 lung cancer cells was evaluated after a 24-hour treatment period. C alata extract was cytotoxic in parental and caspase-9 negative, but not caspase 3 and 8 negative A549 cells. The IC50 values were 143 μg/ml and 145 μg/ml in parental and caspase 9 negative A549 cells respectively. The flavanoid kaempferol was identified as a constituent of C alata leaf extract. These results suggest a cytotoxic effect of C alata that is dependent on caspase 8.
Objective: To evaluate the cytotoxic effect of a hexane extract of Cassia alata leaves in A549 lung cancer cells.
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 03 Feb, 2014
Subscribe to RSS - Caspase 8
Top of Page