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Cassia alata

Anti-inflammatory Activities of Cassia alata Leaf Extract in Complete Freund’s Adjuvant Arthritis in Rats

Issue: 
Pages: 
615–21
Synopsis: 
The anti-inflammatory effects of Cassia alata leaf extract were investigated on complete Freund’s adjuvant induced arthritic rats. The extract from the leaves was able to significantly reduce the swelling observed in the knee joint. It was also able to effectively protect the articular cartilage from degradation as well as limit the number of differential leukocytes entering the synovial cavity during inflammation. Cassia alata possesses potent anti-inflammatory effects and should undergo further investigations of these properties.
 
ABSTRACT
 
Objective: To investigate the anti-inflammatory effects of a hexane extract of Cassia alata leaves in complete Freund’s adjuvant (CFA) arthritis in rats.
 
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e-Published: 03 Feb, 2014

Cassia alata Leaf Extract Induces Cytotoxicity in A549 Lung Cancer Cells via a Mechanism that is Caspase 8 Dependent

Issue: 
Pages: 
608–14
Synopsis: 
The cytotoxic effect of a hexane extract of Cassia alata (C alata) leaves in parental and Caspase 8, 3 and 9 negative A549 lung cancer cells was evaluated after a 24-hour treatment period. C alata extract was cytotoxic in parental and caspase-9 negative, but not caspase 3 and 8 negative A549 cells. The IC50 values were 143 μg/ml and 145 μg/ml in parental and caspase 9 negative A549 cells respectively. The flavanoid kaempferol was identified as a constituent of C alata leaf extract. These results suggest a cytotoxic effect of C alata that is dependent on caspase 8.
 
 
ABSTRACT
 
Objective: To evaluate the cytotoxic effect of a hexane extract of Cassia alata leaves in A549 lung cancer cells.
 
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e-Published: 03 Feb, 2014
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