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Cytotoxicity

A Potential Role for the Antidiabetic Drug Metformin in the Treatment of Platinum Resistant Ovarian Cancer

Issue: 
DOI: 
10.7727/wimj.2015.456
Pages: 
674–78
Synopsis: 
The ability of metformin to enhance the cytotoxic profile of carboplatin in platinum resistant OVCAR3 ovarian cancer cells was evaluated alone and in the presence of the FAK inhibitor PF-5733228. Metformin significantly increased OVCAR3 sensitivity to both carboplatin and PF-573228.

ABSTRACT

Accepted: 
08 Sep, 2015
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e-Published: 12 Feb, 2016

Cassia alata Leaf Extract Induces Cytotoxicity in A549 Lung Cancer Cells via a Mechanism that is Caspase 8 Dependent

Issue: 
Pages: 
608–14
Synopsis: 
The cytotoxic effect of a hexane extract of Cassia alata (C alata) leaves in parental and Caspase 8, 3 and 9 negative A549 lung cancer cells was evaluated after a 24-hour treatment period. C alata extract was cytotoxic in parental and caspase-9 negative, but not caspase 3 and 8 negative A549 cells. The IC50 values were 143 μg/ml and 145 μg/ml in parental and caspase 9 negative A549 cells respectively. The flavanoid kaempferol was identified as a constituent of C alata leaf extract. These results suggest a cytotoxic effect of C alata that is dependent on caspase 8.
 
 
ABSTRACT
 
Objective: To evaluate the cytotoxic effect of a hexane extract of Cassia alata leaves in A549 lung cancer cells.
 
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e-Published: 03 Feb, 2014

Cytotoxic Activity of Selected West Indian Medicinal Plants against a Human Leukaemia Cell Line

Issue: 
Pages: 
597–601
Synopsis: 
Crude methanolic extracts and solvent fractions of the aerial parts of Spermacoce verticillata, Ficus pumila and Flemingia strobilifera showed cytotoxic activity against a human leukaemia cell line. However, chloroform and butanol fractions of F pumila had significantly lower IC50 values.

ABSTRACT

Objective: To assess the cytotoxic activities of crude extracts and solvent fractions of Spermacoce verticillata, Ficus pumila and Flemingia strobilifera against a MT-4 human leukaemia cancer cell line.

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e-Published: 15 Oct, 2013
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