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familial mediterranean fever

Clinical Profile of Familial Mediterranean Fever in a Paediatric Population in Eastern Turkey

Issue: 
DOI: 
10.7727/wimj.2014.173
Pages: 
281–6
Synopsis: 
Familial Mediterranean fever is a frequently seen chronic inflammatory disease that can lead to severe morbidity and mortality if left untreated. Severity and frequency of attacks are correlated with mutations. However, environmental factors play an important role as the clinical course can differ even in people with mutations.

ABSTRACT

Objective: Clinical and genetic findings of familial Mediterranean fever (FMF) may vary in different populations. Environmental factors may also affect phenotypic features of FMF. In this study, we investigated demographic, clinical and mutational features of FMF patients treated in a single reference hospital in Turkey.

Accepted: 
12 Aug, 2014
PDF Attachment: 
Journal Sections: 
e-Published: 11 May, 2015

E148Q as A Familial Mediterranean Fever-Causing Mutation: A Clinical-Based Study

DOI: 
10.7727/wimj.2016.162
Synopsis: 
Familial Mediterranean fever is a genetic disease. M694V, V726A, M680I, M694I and E148Q are the most frequent mutations. The role of E148Q is still controversial. Our aim was to evaluate the E148Q mutation and compare it with other FMF-causing mutations.

ABSTRACT

Objective: To evaluate the clinical implications of E148Q mutation in familial Mediterranean fever (FMF) patients and compare it with other FMF causing mutations.

Methods: The clinical features of 137 FMF patients with E148Q have been evaluated. Moreover, the clinical features of those patients have been compared with the clinical symptoms of FMF patients with other mutations.

Accepted: 
11 Jul, 2016
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Journal Sections: 
Journal Authors: 
e-Published: 19 Jul, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Mediterranean Fever Gene Mutations in Greek Patients with Behcet’s Disease

Issue: 
Pages: 
28–31
Synopsis: 
Pyrin gene mutations in Greek patients with Behçet’s disease are not more common than the general population.

 

ABSTRACT

Objective: It is known that clinical similarities between Behcet’s disease and Familial Mediterranean Fever have led to the hypothesis of a common pathogenesis. Familial Mediterranean Fever is caused by MEFV gene mutations coding for pyrin. Therefore, we examined whether these pyrin mutations are also associated with Behcet’s disease.

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Journal Sections: 
e-Published: 19 Aug, 2013
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