It has been suggested that low-level mean platelet volume (MPV) in humans may be related to secondary thrombosis due to inflammation. For this reason, MPV can be used as a marker showing inflammation in the body. In this study, we found a strong association between MPV and erythrocyte sedimentation rate and C-reactive protein in patients with rheumatic diseases. Thus, MPV may be used as a negative acute-phase reactant in rheumatic diseases.

Mean platelet volume (MPV), a surrogate marker of platelet function, was found to be associated with inflammatory diseases. Results showed that MPV was significantly lower in patients with nasal polyps compared to control subjects.

In this group of patients, ultrasonograplry and leucocyte counts were not adequately sensitive to be useful as discriminating diagnostic tools in patients with suspected acute appendicitis