L-ornithine L-aspartate

Effect of L-ornithine L-aspartate on Liver Injury Due to Acute Ethyl Alcohol Intoxication in Rats

Issue:

Vol 64, Issue 3: June (2015)

DOI:

10.7727/wimj.2014.325

Pages:

189–94

Synopsis:

Acute ethyl alcohol intoxication and related acute alcoholic hepatitis pose serious problems to emergency departments. Reactive oxygen radicals play an important role in ethyl alcohol-induced hepatotoxicity. L-ornithine L-aspartate significantly reduced hepatic injury and decreased oxidative stress causing liver injury.

ABSTRACT

Objective: Ethyl alcohol is a substance that is widely used worldwide and known to exert toxic effects on liver. In this study, we aimed to examine the effect of L-ornithine L-aspartate (LOLA) on the toxicity of a single dose of ethyl alcohol in rats.

Received:

19 Nov, 2014

Accepted:

25 Mar, 2015

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