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E Sogut

Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels Streptozotocin Induced Diabetic Rats

Issue: 
DOI: 
10.7727/wimj.2016.106
Pages: 
61-8
Synopsis: 
Leptin and endothelin (ET), as important endogenous factors, interact with each other which may contribute to a better understanding of their role in diabetic pathogenesis. We aimed to evaluate the relationship between leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on leptin levels in rats with diabetes induced by streptozotocin (STZ). In this study, 24 male, Wistar-albino rats were divided into three groups: Control, STZ, STZ + BQ-123 groups. BQ-123 relatively reduced oxidative stress and leptin levels. ETAR antagonist BQ-123 has positive impacts, depending on the dosage in the diabetic rats.

ABSTRACT 

Objective: Leptin and endothelin (ET) as important endogenous factors interacting with each other which may contribute to a better understanding of their role in diabetic pathogenesis. We aimed to evaluate the relationship between leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on leptin levels in rats with diabetes induced by streptozotocin (STZ).

Accepted: 
25 May, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 07 Jul, 2016
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