Bronchial asthma is a common respiratory disease. This study aimed to explore the effect of 1,25-dihydroxy vitamin D3 (1,25(OH)2D3) on the expression of interleukin-17 and -21 in asthma by establishing an asthma mice model.

Compelling evidence proves that bronchial smooth muscle mass significantly increases in asthmatics, and chronic formoterol administration induces impaired bronchoprotection. No significant difference was detected in increased smooth muscle mass, implying that some other molecular mechanisms might be involved.