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DO Ogbolu

Carbapenem Resistance in Gram-negative Bacteria in South-western Nigeria: The Role of Extended-spectrum β-lactamase CTX-M-15

Issue: 
DOI: 
10.7727/wimj.2017.122
Pages: 
344-9
Synopsis: 
A previous study by the authors identified carbapenemases as a cause of carbapenem resistance in Gram-negative bacteria from Nigeria. There remained carbapenem-resistant isolates without production of a carbapenemase. This study demonstrated that extended-spectrum β-lactamases (largely CTX-M-15) with protein loss was an important mechanism underpinning carbapenem resistance.

ABSTRACT

Objective: To determine the role of extended-spectrum β-lactamases in carbapenem-resistant Gram-negative bacteria from south-western Nigeria.

Accepted: 
15 Dec, 2017
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Journal Sections: 
Journal Authors: 
e-Published: 18 Dec, 2017
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