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carbapenem

Carbapenem Resistance in Gram-negative Bacteria in South-western Nigeria: The Role of Extended-spectrum β-lactamase CTX-M-15

Issue: 
DOI: 
10.7727/wimj.2017.122
Pages: 
344-9
Synopsis: 
A previous study by the authors identified carbapenemases as a cause of carbapenem resistance in Gram-negative bacteria from Nigeria. There remained carbapenem-resistant isolates without production of a carbapenemase. This study demonstrated that extended-spectrum β-lactamases (largely CTX-M-15) with protein loss was an important mechanism underpinning carbapenem resistance.

ABSTRACT

Objective: To determine the role of extended-spectrum β-lactamases in carbapenem-resistant Gram-negative bacteria from south-western Nigeria.

Accepted: 
15 Dec, 2017
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 18 Dec, 2017

Detection of OXA Carbapenemase Positive Acinetobacter spp., Jamaica

DOI: 
10.7727/wimj.2016.065
Synopsis: 
This article looks at the mechanism of carbapenem resistance and clonality of multidrug resistant Acinetobacter spp. at a hospital in Jamaica. PCR found that many of these isolates, some of which are clonally related, were carbapenemase producers.

ABSTRACT

Objective:  The global problem of resistance to carbapenem antibiotics, through the production of carbapenemases by clinically significant bacteria, continues to increase while options for antibiotic therapy remain limited. It is important to determine the mechanism of carbapenem resistance in the multidrug resistant (MDR) Acinetobacter spp.  isolated at a tertiary care hospital, Jamaica (TCHJ) because of the implications for therapy which is the goal of this study.

Accepted: 
20 Apr, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 27 Apr, 2016

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Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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