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DW Seccombe

An Assessment of the Accuracy of Creatinine Measurements in Guyana

DOI: 
10.7727/wimj.2015.518
Pages: 
Synopsis: 
Accuracy of creatinine measurements in sixteen Guyanese medical laboratories was assessed using blinded creatinine reference specimens. Creatinine methods in use in Guyana demonstrated imprecision and bias such that routine reporting of eGFR cannot be recommended at this time,

ABSTRACT

Background: The incidence of chronic kidney disease (CKD) is relatively high in Guyana.  eGFR (estimated glomerular filtration rate) reporting allows for early-stage CKD identification, when therapeutic interventions can prevent CKD progression.  Accurate creatinine measurements are essential for valid eGFR calculations.  This study was undertaken to assess the accuracy of creatinine measurements in Guyana prior to implementing routine eGFR reporting.

Accepted: 
26 Oct, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 10 Jul, 2017

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Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

An Assessment of the Accuracy of Creatinine Measurements in Guyana

DOI: 
10.7727/wimj.2015.518
Synopsis: 
The accuracy of creatinine measurements in sixteen Guyanese medical laboratories was assessed using blinded creatinine reference specimens. Creatinine methods in use in Guyana demonstrated imprecision and bias such that routine reporting of estimated glomerular filtration rate (eGFR) cannot be recommended at this time.

ABSTRACT

Background: The incidence of chronic kidney disease (CKD) is relatively high in Guyana. Estimated glomerular filtration rate (eGFR) reporting allows for early-stage CKD identification, when therapeutic interventions can prevent CKD progression.  Accurate creatinine measurements are essential for valid eGFR calculations. This study was undertaken to assess the accuracy of creatinine measurements in Guyana prior to implementing routine eGFR reporting.

Accepted: 
26 Oct, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 01 Jun, 2017

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

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