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Adding haemoglobin to total lymphocyte count improves the sensitivity of the marker to predict CD4 count <200/mm3, thus ensuring initiation of highly active antiretroviral therapy and thereby reducing investigational costs.
Aim: To find a sensitive and low-cost surrogate marker for CD4 count for initiating highly active antiretroviral therapy (HAART) [CD4 < 200 /mm3], in the form of total lymphocyte count (TLC) < 1200 /mm3 combined with haemoglobin (Hb) with multiple Hb cut-offs.