Intracranial neurovascular manifestations in sickle cell disease include cerebral infarction, parenchymal and epidural haemorrhage, subarachnoid haemorrhage with single or multiple aneurysms, Moyamoya syndrome and posterior reversible ischemic encephalopathy.
Adding haemoglobin to total lymphocyte count improves the sensitivity of the marker to predict CD4 count <200/mm3, thus ensuring initiation of highly active antiretroviral therapy and thereby reducing investigational costs.
ABSTRACT
Aim: To find a sensitive and low-cost surrogate marker for CD4 count for initiating highly active antiretroviral therapy (HAART) [CD4 < 200 /mm3], in the form of total lymphocyte count (TLC) < 1200 /mm3 combined with haemoglobin (Hb) with multiple Hb cut-offs.
The study evaluated the measurement of HbA1c in stored whole blood samples and the results showed that the effect of storage degradation product was not significant enough to compromise the clinical or research use of HbA1c test results from stored whole blood samples.