N Karadayı

Presence of Human Papillomavirus and Epstein–Barr Virus in Squamous Lesions of the Tongue

Issue:

Vol 69, Issue 6: 2021

DOI:

10.7727/wimj.2015.329

Pages:

391-4

Synopsis:

Twenty-three tongue biopsies were detected immunohistochemically for p16, Epstein–Barr virus (EBV) and Ki67, and real-time PCR and chromogenic in-situ hybridization for human papillomavirus (HPV). Evidence suggested that HPV infection plays a role in the pathogenesis of squamous dysplasia localized on the tongue, but not EBV infections.

ABSTRACT

Background: Several studies have suggested a possible role of human papillomavirus (HPV) and Epstein–Barr virus in the pathogenesis of oral premalignant lesions. This study aimed to investigate the correlation between squamous dysplasia of the tongue and expression of p16 and Ki67 immunohistochemically as well as HPV genotypes with real-time polymerase chain reaction (PCR).

Received:

22 Jun, 2015

Accepted:

24 Aug, 2015

Published:

10 Dec, 2021

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