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PCR

Presence of Human Papillomavirus and Epstein–Barr virus in Squamous Lesions of the Tongue

DOI: 
10.7727/wimj.2015.329
Synopsis: 
Twenty-three tongue biopsies were detected immunohistochemically for p16, Epstein-Barr virus (EBV) and Ki67, and Real-time PCR and chromogenic in-situ hybridization for human papillomavirus (HPV). Evidence suggested that HPV infection plays a role in the pathogenesis of squamous dysplasia localized on the tongue, but not EBV infections.

ABSTRACT

Background: Several studies have suggested a possible role of human papillomavirus (HPV) and Epstein-Barr virus (EBV) in the pathogenesis of oral premalignant lesions. This study aimed to investigate the correlation between squamous dysplasia of the tongue and expression of p16 and Ki67 immunohistochemically as well as HPV genotypes with Real-time PCR.

Accepted: 
24 Aug, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 10 Mar, 2016

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Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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