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vascular reactivity

Specificity of Vascular Reactivity and Altered Response in Experimental Malaria

Issue: 
Pages: 
330–5
Synopsis: 
The direct interaction between the parasitized erythrocytes and vascular endothelial cells altered contractile responses in vascular rings. The regulation of vascular tone by various vasoactive agents following exposure to malaria parasites might be altered in a vessel-specific manner.

ABSTRACT

Objective: Adherence of erythrocytes infected with Plasmodium falciparum (P falciparum) to microvascular endothelial cells (sequestration) is considered to play an important role in parasite virulence and pathogenesis. In this study, we have examined the possibility that there is altered vascular reactivity due to the direct interaction between the parasitized erythrocytes and vascular endothelial cells and that it could be tissue specific.

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e-Published: 31 Jan, 2014
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