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Dengue

Meningo-encephalo-myelitis in Children during the Zika Virus Epidemic in Grenada

Issue: 
DOI: 
10.7727/wimjopen.2017.227
Pages: 
43–6
Synopsis: 
Zika Virus is neurotropic. We report two children from the Caribbean Island of Grenada, a three-year-old with acute neuro-inflammation who had intractable seizures, meningo-encephalitis, CSF pleocytosis and Zika IgM positive acute serology and a four-year-old with acute demyelinating encephalomyelitis manifesting as generalized seizures, optic neuritis, diffuse cerebral dysfunction, encephalopathy, impaired speech and ataxia who also had CSF pleocytosis as well as Zika IgM and Dengue IgM positive acute serologies. Both cases occurred during the 2016 Zika and Dengue fever epidemic in Grenada. Both children recovered completely. The aetiologic role of the Zika and Dengue arboviruses is discussed.

Zika Virus is neurotropic. We report two children from the Caribbean Island of Grenada, a three-year-old with acute neuro-inflammation who had intractable seizures, meningo-enceph-alitis, cerebrospinal fluid (CSF) pleocytosis and Zika Immunoglobulin M (IgM) positive acute serology and a four-year-old with acute demyelinating encephalomyelitis manifesting as generalized seizures, optic neuritis, diffuse cerebral dysfunction, encephalopathy, impaired speech and ataxia who also had CSF pleocytosis as well as Zika IgM and Dengue IgM positive acute serologies.

Accepted: 
December 18, 2017
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Outcome of Dengue in Hospitalized Jamaican Children

Issue: 
DOI: 
10.7727/wimjopen.2016.525
Pages: 
25-32
Synopsis: 
Before the emergence of Zika in 2016 and Chikungunya in 2014, there have been numerous Dengue outbreaks in the Caribbean. Despite this, there is a paucity of published studies on Dengue in children from this region. The potential for exponential spread of the Aedes aegypti dengue vector and its deleterious outcomes in children underlines the importance of this paper.

Background: Dengue fever is hyper-endemic in Jamaica with exponential rates of infection in successive outbreaks. The absence of local data and the potential for massive outbreaks in a country where a third of the population are children formed the basis for this study. 

Accepted: 
December 26, 2015
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Emergence of Zika Virus Epidemic and the National Response in Jamaica

Issue: 
DOI: 
10.7727/wimjopen.2016.488
Pages: 
5-11
Synopsis: 
The Zika virus epidemic in Jamaica is evolving and includes cases of Guillain-Barré Syndrome and reports in pregnant women. Zika may become endemic in Jamaica, similar to dengue and Chikungunya. Safe and effective Dengue, Chikungunya fever and ZIKV vaccines are needed to mitigate the devastating effects of these three diseases.

Background: Jamaica, along with the Americas, experienced major epidemics of arboviral diseases transmitted by the Aedes aegypti mosquito in recent years. These include: Dengue fever in 2012, Chikungunya fever in 2014 and Zika virus infection (ZIKV) in 2016. We present the emergence of the ZIKV epidemic in Jamaica and outline the national response.

Accepted: 
September 28, 2016
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Journal Sections: 

Chikungunya in Jamaica – Public Health Effects and Clinical Features in Children

Issue: 
DOI: 
10.7727/wimjopen.2016.529
Pages: 
18-24
Synopsis: 
The Chikungunya fever epidemic had significant public health and economic impact in Jamaica. In children, there were characteristic presentations in neonates and young infants and in children six months to six years. Neurologic involvement was common but other organ dysfunction was rare.

Background: Chikungunya virus entered the Caribbean for the first time in 2013 and Jamaica experienced its maiden epidemic with Chikungunya fever in 2014. We aimed to describe the public health effects and describe the clinical features in children and adolescents in Jamaica.

Accepted: 
October 26, 2016
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Journal Sections: 
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