Zika Virus is neurotropic. We report two children from the Caribbean Island of Grenada, a three-year-old with acute neuro-inflammation who had intractable seizures, meningo-enceph-alitis, cerebrospinal fluid (CSF) pleocytosis and Zika Immunoglobulin M (IgM) positive acute serology and a four-year-old with acute demyelinating encephalomyelitis manifesting as generalized seizures, optic neuritis, diffuse cerebral dysfunction, encephalopathy, impaired speech and ataxia who also had CSF pleocytosis as well as Zika IgM and Dengue IgM positive acute serologies.

Background: Chikungunya virus entered the Caribbean for the first time in 2013 and Jamaica experienced its maiden epidemic with Chikungunya fever in 2014. We aimed to describe the public health effects and describe the clinical features in children and adolescents in Jamaica.

Dengue, Chikungunya fever (CHIKV) and Zika virus (ZIKV) are all transmitted by the Aedes aegypti mosquito and are currently circulating in Jamaica. Jamaica has been experiencing a ZIKV epidemic since February 2016. At the University Hospital of the West Indies (UHWI), Kingston, Jamaica, a cluster of five cases of paralysis attributed to neuro-inflammation was noted amongst adolescents admitted to the Institution. Three were diagnosed with acute myelitis and one each with acute disseminated encephalomyelitis (ADEM) and Guillain-Barre Syndrome (GBS).