The microenvironment of multiple myeloma (MM), composed of different cells, is influenced by the massive presence of neoplastic plasma cells. Osteoblastic suppression and osteoclast induction is one of the tumour stimuli. Simvastatin protects osteoblasts from the deleterious effects of the liquid milieu of MM.

Quantities of biochemical signals interleukin-1α (IL-1α), IL-6, IL-8, IL-11, macrophage colony stimulating factor and osteocalcin produced by osteosarcoma cell line MG 63 are different in the presence of titanium (Ti), titanium alloy (Ti6A14V) and stainless steel implant materials.