The HLA dengue associations in Jamaicans differ from
those found in other ethnic populations. While HLA-A
*24 and – DRβ5* 01/02 were associated with having
dengue, HLA-A *23, -CW*04, -DQβ*02, DQβ*03 and
–DQβ*06 were protective.
Background: Polymorphisms in the human leukocyte antigen (HLA) genes might predispose certain individuals to dengue fever (DF) and the severe forms of the disease: dengue haemorrhagic fever/ dengue shock syndrome (DHF/DSS).
A study of dengue viruses that were in circulation in
Jamaica in 2007 identified strains of DENV-1 genotype
III, DENV-2 strains of the American, American-Asian
and Asian genotypes while DENV-4 strains segregated
into a separate clade from published reference
A study of the dengue viruses that were in circulation
showed that all 4 serotypes were in circulation during
2003–2007 and the most prevalent were dengue
serotypes 2 and 4.
Background: Dengue virus (DENV) infection is increasing in prevalence and severity globally. The severity of dengue is influenced by several factors including the immune response, viral and host genetic factors.