The HLA dengue associations in Jamaicans differ from
those found in other ethnic populations. While HLA-A
*24 and – DRβ5* 01/02 were associated with having
dengue, HLA-A *23, -CW*04, -DQβ*02, DQβ*03 and
–DQβ*06 were protective.
Background: Polymorphisms in the human leukocyte antigen (HLA) genes might predispose certain individuals to dengue fever (DF) and the severe forms of the disease: dengue haemorrhagic fever/ dengue shock syndrome (DHF/DSS).
A study of dengue viruses that were in circulation in
Jamaica in 2007 identified strains of DENV-1 genotype
III, DENV-2 strains of the American, American-Asian
and Asian genotypes while DENV-4 strains segregated
into a separate clade from published reference
A study of the dengue viruses that were in circulation
showed that all 4 serotypes were in circulation during
2003–2007 and the most prevalent were dengue
serotypes 2 and 4.
Background: Dengue virus (DENV) infection is increasing in prevalence and severity globally. The severity of dengue is influenced by several factors including the immune response, viral and host genetic factors.
Patients from two tertiary referral hospitals were assessed to determine whether Type 2 diabetes mellitus was present in Jamaican diabetic youth. Type 2 diabetes accounted for 22% of cases. Obesity was the most important clinical predictor of Type 2 diabetes.
Objectives: To assess the frequency of youth onset Type 2 diabetes mellitus (T2D) in Jamaica and the characteristics of youth with this form of diabetes.
In this study, there was a high prevalence of cardiovascular risk factors in the patients studied regardless of their diabetes type. While patients with Type 2 diabetes mellitus were more obese and had higher blood pressure readings when compared with those with Type1 diabetes, their overall glucose control was better. Differences in lipid profile were no longer significant after adjusting for BMI.
Objective: To assess the effect of diabetes mellitus type on conventional and novel cardiovascular risk factors in patients, diagnosed with diabetes from two major referral hospitals in Jamaica, before age 25 years and with diabetes duration < 6 years.
Molecular epidemiological studies of Methicillin resistant coagulase-negative Staphylococci provide important information on its spread in healthcare facilities and the clinical significance in individual
A cross-sectional study in which DNA HLA typing methods were used to investigate the associations between HLA and class II alleles and the presence of systemic lupus erythematosus and antinuclear antibodies (ANA) in Jamaicans. The HLA associations with ANA were similar to those found in other ethnic groups, but no significant positive HLA association with SLE was found.
Objective: The relationship between human leukocyte antigens class II (HLA) and antinuclear antibodies was investigated in Jamaican patients with Systemic Lupus Erythematosus (SLE).
This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.