The HLA dengue associations in Jamaicans differ from
those found in other ethnic populations. While HLA-A
*24 and – DRβ5* 01/02 were associated with having
dengue, HLA-A *23, -CW*04, -DQβ*02, DQβ*03 and
–DQβ*06 were protective.
Background: Polymorphisms in the human leukocyte antigen (HLA) genes might predispose certain individuals to dengue fever (DF) and the severe forms of the disease: dengue haemorrhagic fever/ dengue shock syndrome (DHF/DSS).
A study of dengue viruses that were in circulation in
Jamaica in 2007 identified strains of DENV-1 genotype
III, DENV-2 strains of the American, American-Asian
and Asian genotypes while DENV-4 strains segregated
into a separate clade from published reference
A study of the dengue viruses that were in circulation
showed that all 4 serotypes were in circulation during
2003–2007 and the most prevalent were dengue
serotypes 2 and 4.
Background: Dengue virus (DENV) infection is increasing in prevalence and severity globally. The severity of dengue is influenced by several factors including the immune response, viral and host genetic factors.
Some antibiotics, in addition to their antimicrobial effects, modify the host immune response. Cotrimoxazole unIike ciprofloxacin, ceftazidime, and piperacillintazobactam suppressed TNF alpha secretion from S maltophilia stimulated cells at therapeutic concentrations.
The majority of strains of HIV-1 isolated from HIV-1 infected individuals in Jamaica were found to be HIV- 1 subtype B. The less frequently found HIV-1 subtypes were C, D and E and some strains were untypable by the methods used.