S Li

Cytokine-induced Killer Cells Co-cultured with Dendritic Cell Benefit for the Treatment of MCF-7/ADR-Mammary Cancer with Multi-drug Resistance

DOI:

10.7727/wimj.2015.474

Synopsis:

After cytokine-induced killer cells (CIK) were co-cultured with dendritic cells (DC) loaded with multi-drug resistance tumor antigen, the higher antitumour immune response was evaluated to multi-drug resistance tumor expressed as the same tumour antigen. This provided the effective, clinical treatment for the multi-drug resistance tumour.

ABSTRACT

Cytokine-induced killer cells (CIK) are capable of lysing tumor cell and recognizing these cells in a non-MHC restricted fashion. After they were co-cultured with Dendritic cells (DC) loaded multidrug resistance tumor antigen, do they have the higher antitumor effect to the same multidrug resistance tumor?

Received:

01 Sep, 2015

Accepted:

11 Sep, 2015

PDF Attachment:

li20et20al-cik20cocultured20with20dc1.pdf

Journal Sections:

Original Articles

Keywords:

Cytokine-induced killer cells

dendritic cells

Multiple-drug resistance

MCF-7/ADR

Journal Authors:

S Li

H Pang

e-Published: 03 Nov, 2015

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Treatment of Parapelvic Cyst by Internal Drainage Technology Using Ureteroscope and Holmium Laser

Issue:

Vol 64, Issue 3: June (2015)

DOI:

10.7727/wimjopen.2014.220

Pages:

230–5

Synopsis:

We explored the efficacy and safety of surgical approaches with holmium laser ureteroscopic internal drainage in the treatment of parapelvic cyst. In 28 cases of operation, 27 cases were successful. Our study shows that the treatment of parapelvic cyst by internal drainage operation using holmium laser and ureteroscopy had very good result with few complications.

ABSTRACT

Background: The aim of parapelvic cyst treatment is to have complete drainage of cyst fluid and prevent its further compression of the kidney and collective system. This study explores the efficacy and safety of surgical approaches with holmium laser ureteroscopic internal drainage in the treatment of parapelvic cyst.

Received:

28 Apr, 2014

Accepted:

17 Sep, 2014

PDF Attachment:

wimjjun2015_230_235.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 14 Sep, 2015

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Survival of Cochlear Spiral Ganglion Neurons Improved in vitro by Anti-miR204 via TMPRSS3

Issue:

Vol 65, Issue 2: 2016

DOI:

10.7727/wimj.2014.393

Pages:

379-82

Synopsis:

The survival of cochlear spiral ganglion neurons was increased in mice with kanamycin ototoxicity whose cochlea were micro-injected with AAV1-anti-miR204, which suggested that anti-miR204 could be a potential therapeutic strategy in sensorineural hearing loss.

ABSTRACT

Objective: Sensorineural hearing loss (SNHL) is caused by damage to hair cells followed by degeneration of the spiral ganglion neurons (SGNs) and cochlear implanting is an effective treatment. Unfortunately, the progressive hearing loss is still found due to ongoing degeneration of cochlear SGNs. The aim of this study was to investigate the neuroprotective effect of antimiR204 on SGNs in vivo.

Received:

04 Dec, 2014

Accepted:

05 Jan, 2015

PDF Attachment:

wimj_iss2_2016_379-82.pdf

Journal Sections:

Short Communication

Keywords:

MiR204

Kanamycin ototoxicity

sensorineural hearing loss