Kanamycin ototoxicity

Survival of Cochlear Spiral Ganglion Neurons Improved in vitro by Anti-miR204 via TMPRSS3

Issue:

Vol 65, Issue 2: 2016

DOI:

10.7727/wimj.2014.393

Pages:

379-82

Synopsis:

The survival of cochlear spiral ganglion neurons was increased in mice with kanamycin ototoxicity whose cochlea were micro-injected with AAV1-anti-miR204, which suggested that anti-miR204 could be a potential therapeutic strategy in sensorineural hearing loss.

ABSTRACT

Objective: Sensorineural hearing loss (SNHL) is caused by damage to hair cells followed by degeneration of the spiral ganglion neurons (SGNs) and cochlear implanting is an effective treatment. Unfortunately, the progressive hearing loss is still found due to ongoing degeneration of cochlear SGNs. The aim of this study was to investigate the neuroprotective effect of antimiR204 on SGNs in vivo.

Received:

04 Dec, 2014

Accepted:

05 Jan, 2015

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