Clinical adverse events

The Effect of Hydroxyurea therapy on Adverse Clinical Events and Haematological Indices in Paediatric Patients with Sickle Cell Anaemia

Issue:

Vol 68, Issue 2: 2019

DOI:

10.7727/wimj.2015.538

Pages:

80–85

Synopsis:

The vast majority of available evidence on the efficacy, effectiveness and safety of hydroxyurea in childhood sickle cell anaemia (SCA) is mostly from high-income countries. The conclusions drawn from this study would be useful in guiding hydroxyurea use in other less developed countries with limited resources.

ABSTRACT

Objective: The aim of this study was to determine the effect of hydroxyurea on adverse clinical events and haematological indices in paediatric patients with sickle cell anaemia.

Method: This study compared the same cohort of patients before and after hydroxyurea therapy, monitoring the rate of adverse events, pre- and post-treatment and haematological indices.

Received:

02 Nov, 2015

Accepted:

17 Nov, 2015

Published:

28 Jan, 2020

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