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K Maharaj

The Effect of Hydroxyurea therapy on Adverse Clinical Events and Haematological Indices in Paediatric Patients with Sickle Cell Anaemia

Issue: 
DOI: 
10.7727/wimj.2015.538
Pages: 
80–85
Synopsis: 
The vast majority of available evidence on the efficacy, effectiveness and safety of hydroxyurea in childhood sickle cell anaemia (SCA) is mostly from high-income countries. The conclusions drawn from this study would be useful in guiding hydroxyurea use in other less developed countries with limited resources.

ABSTRACT

Objective: The aim of this study was to determine the effect of Hydroxyurea on adverse clinical events and haematological indices in paediatric patients with sickle cell anaemia.

Method: This study compared the same cohort of patients before and after Hydroxyurea therapy monitoring the rate of adverse events pre and post treatment and haematological indices.

Accepted: 
17 Nov, 2015
Journal Sections: 
e-Published: 31 Mar, 2016

C-reactive Protein: Adjunct to Cardiovascular Risk Assessment

Issue: 
Pages: 
551–5
Synopsis: 
Prevention of cardiovascular disease is well-described. However, a significant gap lies in the detection of at-risk persons who should be targeted for intervention. Can C-reactive protein be an effective adjunct to cardiovascular risk assessment.

ABSTRACT

Objectives: The study aimed to investigate whether elevated plasma high sensitivity C-reactive protein (hs-CRP) levels are independently associated with an increased risk of cardiovascular disease (CVD) and to then assess the effectiveness of the addition of hs-CRP testing to cardiovascular risk assessment by standard lipid screening.

PDF Attachment: 
Journal Sections: 
e-Published: 20 Sep, 2013
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