K Maharaj

The Effect of Hydroxyurea therapy on Adverse Clinical Events and Haematological Indices in Paediatric Patients with Sickle Cell Anaemia

Issue:

Vol 68, Issue 2: 2019

DOI:

10.7727/wimj.2015.538

Pages:

80–85

Synopsis:

The vast majority of available evidence on the efficacy, effectiveness and safety of hydroxyurea in childhood sickle cell anaemia (SCA) is mostly from high-income countries. The conclusions drawn from this study would be useful in guiding hydroxyurea use in other less developed countries with limited resources.

ABSTRACT

Objective: The aim of this study was to determine the effect of hydroxyurea on adverse clinical events and haematological indices in paediatric patients with sickle cell anaemia.

Method: This study compared the same cohort of patients before and after hydroxyurea therapy, monitoring the rate of adverse events, pre- and post-treatment and haematological indices.

Received:

02 Nov, 2015

Accepted:

17 Nov, 2015

Published:

28 Jan, 2020

PDF Attachment:

wimj-iss2-2019_80_85_2.pdf

Journal Sections:

Original Articles

Keywords:

Sickle Cell Disease

Clinical adverse events

haematological indices

Journal Authors:

e-Published: 31 Mar, 2016

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C-reactive Protein: Adjunct to Cardiovascular Risk Assessment

Issue:

Vol 58, issue 6 (2009)

Pages:

551–5

Synopsis:

Prevention of cardiovascular disease is well-described. However, a significant gap lies in the detection of at-risk persons who should be targeted for intervention. Can C-reactive protein be an effective adjunct to cardiovascular risk assessment.

ABSTRACT

Objectives: The study aimed to investigate whether elevated plasma high sensitivity C-reactive protein (hs-CRP) levels are independently associated with an increased risk of cardiovascular disease (CVD) and to then assess the effectiveness of the addition of hs-CRP testing to cardiovascular risk assessment by standard lipid screening.

PDF Attachment:

dr_bahadursingh_special_issue_december.qxd_.pdf

Journal Sections:

Keywords:

Journal Authors: