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oestradiol

Trona Causes Fetal Loss in Pregnant Rat via an Oestrogen-dependent Mechanism

Issue: 
Vol 65, Issue 1: 2016
DOI: 
10.7727/wimj.2014.254
Pages: 
83–6
Synopsis: 
The study demonstrated that trona causes fetal loss. This could be attributed to the chemical constituents especially sodium and calcium. This effect is possibly via oestrogen-dependent mechanism. This study mainly focussed on the potentials of trona to cause fetal loss and its associated mechanism.

ABSTRACT

 

Background: There is a claim in folklore medicine in Nigeria that trona (a sesquicarbonate or hydrated carbonate of sodium) causes fetal loss. However, this has not been substantiated or refuted by any scientific evidence.

Aim: This study evaluates whether or not trona causes fetal loss in pregnant female Wistar rats.

Received: 
08 Oct, 2014
Accepted: 
31 Oct, 2014
PDF Attachment: 
PDF icon wimj_iss1_2016_83_86.pdf
Journal Sections: 
Original Articles
Keywords: 
oestradiol
progesterone
cholesterol
trona
fetal loss
Bodyweight
Journal Authors: 
AF Ajayi
RE Akhigbe
e-Published: 06 May, 2015

Hypothalamic-pituitary-ovarian Axis in Thyroid Dysfunction

Issue: 
Vol 62, Issue 9: Dec (2013)
DOI: 
10.7727/wimj.2013.038
Synopsis: 
Findings from this study suggest that impairment of reproductive function associated with thyroid dysfunction is in attendant with derangement of hormonal milieu and alteration in reproductive organs cytoarchitecture. Luteinizing hormone and oestradiol are implicated.

ABSTRACT

Background: It has been established that thyroid dysfunction causes impairment of reproductive function. However, laboratory and human studies that associated this with female reproductive hormones are conflicting and data reporting the effects of thyroid dysfunction on reproductive organs are insufficient.

Received: 
20 Feb, 2013
Accepted: 
22 Apr, 2013
PDF Attachment: 
PDF icon ajayi_et_al-hypothalamic-pituitary-ovarian_axis.pdf
Journal Sections: 
Original Articles
Keywords: 
Fertility
hyperthyroidism
hypothyroidism
oestradiol
progesterone
follicle stimulating hormone
luteinizing hormone
Journal Authors: 
AF Ajayi
RE Akhigbe
LO Ajayi
e-Published: 24 Jan, 2014

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

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West Indian Medical Journal

Faculty of Medical Sciences,
The University of the West Indies,
Mona, Kingston 7
Tel: (876) 927-1214
Fax: (876) 927-1846
wimj@uwimona.edu.jm
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