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sickle cell anaemia

A Cross-sectional Clinic-based Study Exploring whether Variants within Genes Coding for Enzymes of the Transmethylation and Trans-sulphuration Pathways Are Associated with Inter-individual Phenotypic Variation in Sickle Cell Anaemia in Jamaica

Issue: 
DOI: 
10.7727/wimj.2017.205
Pages: 
510–7
Synopsis: 
This cross-sectional study explored and generated novel and useable estimates of association between variants within genes underlying the transmethylation and trans-sulphuration pathways and inter-individual phenotypic variation in sickle cell anaemia (HbSS).

ABSTRACT

Accepted: 
25 Oct, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 25 Oct, 2017

Radiological Abnormalities and Asymptomatic Bacteriuria in Patients with Sickle Cell Disease

Issue: 
DOI: 
10.7727/wimj.2017.203
Pages: 
497–502
Synopsis: 
This study investigated the association of radiological abnormalities and asymptomatic bacteriuria in patients with sickle cell disease. No association was seen and there was no increased risk of symptomatic urinary tract infections in these patients.

ABSTRACT

Objective: The prevalence of asymptomatic bacteriuria (ASB) in sickle cell disease (SCD) in Jamaica is 5.3%. This study sought to determine the association between ASB and anatomical urological abnormalities and symptomatic urinary tract infections (UTIs).

Accepted: 
14 Mar, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 05 Oct, 2017

The Use of Analgesic Drugs in Patients with Sickle Cell Painful Crisis

Issue: 
DOI: 
10.7727/wimj.2012.272
Pages: 
479–83
Synopsis: 
Painful crisis in patients with sickle cell anaemia is associated with severe pain in 75% and most will require second line therapy for adequate resolution. Physicians need to provide adequate pain relief to decrease morbidity in these patients.

ABSTRACT

Objective: To determine the drug options used for pain in patients with acute sickle cell painful crisis at the University Hospital of the West Indies (UHWI), Jamaica.

Method: This retrospective study assessed all patients admitted to the UHWI between January 1, 2006 and December 31, 2010 with acute sickle cell anaemia painful crisis and the data obtained regarding site, severity, outcome and drug options selected for pain.

Revised: 
24 Feb, 2013
Accepted: 
12 Mar, 2013
PDF Attachment: 
Journal Sections: 
e-Published: 30 Apr, 2014
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