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Original Articles

Clinical Pathology and Prognostic Analysis of Visceral Metastatic Carcinoma of Unknown Primary Site (VMCUP)

Issue: 
Vol 1, Issue 3 (2014)
DOI: 
10.7727/wimjopen.2013.282
Pages: 
117–120b
Synopsis: 
Comprehensive treatments for visceral metastatic carcinoma of unknown primary site (VMCUP) including surgery and chemotherapy significantly improved patients’ overall survival time. Patients treated mainly by surgery lived longer than those treated by chemotherapy alone. More chemotherapy cycles resulted in longer survival time for patients only receiving chemotherapy. For the first time, this study identified paclitaxel plus fluorouracil as more effective first-line chemotherapy drugs than 5-fluorouracil in treating VMCUP.

ABSTRACT

Objective: To analyse the clinicopathologic characteristics of visceral metastatic carcinoma of unknown primary site (VMCUP), discuss the relationship between its treatment and prognosis, and provide the basis for individualized clinical diagnosis and treatment.

Received: 
October 9, 2013
Accepted: 
December 11, 2013
Published: 
December 22, 2014
PDF Attachment: 
PDF icon Xu et al--Clinical Pathology and Prognostic Analysis of VMCUP.pdf
Journal Sections: 
Original Articles
Keywords: 
prognosis
Internal organs
treatment
visceral metastatic carcinoma of unknown primary site (VMCUP)
Journal Authors: 
Q Xu
T Jiang*
S Yang*
X Wang
J Wang
Q Chen

Role of Different Concentrations of Morphine after Coronary Perfusion for Myocardial Protection

Issue: 
Vol 1, Issue 3 (2014)
DOI: 
10.7727/wimjopen.2013.307
Pages: 
107–10
Synopsis: 
Morphine at concentrations of 2 μmol/L and 4 μmol/L after coronary perfusion on cardiac valve replacement with cardiopulmonary bypass has myocardial protection.

ABSTRACT

Objective: To investigate whether the different concentrations of morphine after coronary perfusion have myocardial protection.

Received: 
November 20, 2013
Accepted: 
November 26, 2013
Published: 
November 6, 2014
PDF Attachment: 
PDF icon Chen et al--Morphine for myocardial protection_1.pdf
Journal Sections: 
Original Articles
Keywords: 
Coronary perfusion
morphine
myocardial protection
Journal Authors: 
S Chen
J Xiong
Y Zhan
W Liu
X Wang

Lurking Threat of Endowasher Contamination – A Cause for Post-endoscopic Infections

Issue: 
Vol 1, Issue 3 (2014)
DOI: 
10.7727/wimjopen.2014.075
Pages: 
103–6
Synopsis: 
Endowashers can be a potential source of infection in post-endoscopic procedures. Routine checking of the water samples for quality control of endowashers should be done to monitor the spread of nosocomial infections by potentially resistant bacteria.

ABSTRACT

Aim: Endowashers are the main source of infection in endoscopy. Therefore, we undertook this study to evaluate endowashers as a source of infection after endoscopic procedures.

Received: 
March 18, 2014
Accepted: 
August 11, 2014
Published: 
November 6, 2014
PDF Attachment: 
PDF icon Zhai et al--Post-endoscopic infection by endowasher.pdf
Journal Sections: 
Original Articles
Keywords: 
Disinfection
endoscopy
endowasher
quality control
reprocessed
samples
Journal Authors: 
Y Zhai
C Zhao
Y Zhang

Glycaemic Control among Patients with Diabetes in Primary Care Clinics in Jamaica, 1995 and 2012

Issue: 
Vol 1, Issue 3 (2014)
DOI: 
10.7727/wimjopen.2014.085
Pages: 
99–102
Synopsis: 
The quality of care received by patients with diabetes in public primary care clinics in 2012 was compared with that received in 1995. There was improvement in the screening, monitoring and counselling of patients in 2012 compared to 1995. However, there was no improvement in glycaemic control.

ABSTRACT

Objective: To compare the quality of care received by patients with diabetes in public primary care clinics in 2012 with that reported in 1995.

Received: 
April 7, 2014
Accepted: 
June 6, 2014
Published: 
November 10, 2014
PDF Attachment: 
PDF icon Harris et al--Glycaemic Control among Patients with Diabetes.pdf
Journal Sections: 
Original Articles
Keywords: 
Jamaica
Clinical audit
diabetes
hypertension
primary care
Journal Authors: 
MA Harris
K James
NK Waldron
TS Ferguson
JP Figueroa

Antigua/Barbuda Cancer Mortality Study

Issue: 
Vol 1, Issue 3 (2014)
DOI: 
10.7727/wimjopen.2014.073
Pages: 
88–91
Synopsis: 
In this study of cancer mortality in Antigua and Barbuda, gender-specific cancers accounted for approximately half of the cancer deaths. Mortality/incidence ratios greater than 1 suggest that there may be incomplete data capture of the incidence.

ABSTRACT

Objective: To determine the cancer mortality rates in Antigua and Barbuda in an effort to enhance the profile of the country’s cancer burden.

Method: Available data for 2001 to 2005 were analysed to obtain cancer mortality rates.  Analysis was also made of the mortality/incidence ratios.

Received: 
March 17, 2014
Accepted: 
June 23, 2014
Published: 
October 24, 2014
PDF Attachment: 
PDF icon Daniel et al--Antigua-Barbuda cancer mortality.pdf
Journal Sections: 
Original Articles
Keywords: 
Cancer
mortality/incidence ratio
mortality rate
Journal Authors: 
GS Daniel
LC Simon
S Goodwin

Antigua/Barbuda Cancer Incidence Study

Issue: 
Vol 1, Issue 3 (2014)
DOI: 
10.7727/wimjopen.2014.072
Pages: 
84–7
Synopsis: 
A five-year retrospective study of cancer occurrence in Antigua/Barbuda revealed that the dominant cancers in this population were breast and cervix uteri in women, and prostate in men.

ABSTRACT

Objective: The Antigua/Barbuda Cancer Study was undertaken to determine the incidence of cancer and describe the cancer distribution by age and gender.

Received: 
March 17, 2014
Accepted: 
June 23, 2014
Published: 
October 24, 2014
PDF Attachment: 
PDF icon Simon et al--Antigua-Barbuda cancer incidence.pdf
Journal Sections: 
Original Articles
Keywords: 
Antigua and Barbuda
cancer incidence
gender-specific cancers
Journal Authors: 
LC Simon
P Gaskin
GS Daniel
J Samuel
S Goodwin

Effects of Momordica charantia Extract on the Expression of MDR 1 Gene in Human Lung Cancer Cells

Issue: 
Vol 1, Issue 3 (2014)
DOI: 
10.7727/wimjopen.2014.147
Pages: 
92–8
Synopsis: 
Multidrug resistance is a major obstacle in the success of cancer chemotherapy. Recent studies have focussed on plant extracts to reverse drug resistance. This study evaluates the efficacy of Momordica charantia extract in reversing drug resistance in small cell carcinoma cell lines.

ABSTRACT

Received: 
June 17, 2014
Accepted: 
June 30, 2014
Published: 
October 24, 2014
PDF Attachment: 
PDF icon Yuan and Li--Effects of Momordica charantia on SCLC.pdf
Journal Sections: 
Original Articles
Keywords: 
Lung cancer
Momordica charantia
multi-drug resistance
P-glycoprotein
Journal Authors: 
T Yuan
H-Y Li

Impaired Bronchoprotection Is Not Induced by Increased Smooth Muscle Mass in Chronic Treatment In Vivo with Formoterol in Asthmatic Mouse Model

Issue: 
Vol 1, Issue 3 (2014)
DOI: 
10.7727/wimjopen.2014.177
Pages: 
78–83
Synopsis: 
Compelling evidence proves that bronchial smooth muscle mass significantly increases in asthmatics, and chronic formoterol administration induces impaired bronchoprotection. No significant difference was detected in increased smooth muscle mass, implying that some other molecular mechanisms might be involved.

ABSTRACT

Received: 
July 24, 2014
Accepted: 
August 11, 2014
Published: 
September 22, 2014
PDF Attachment: 
PDF icon Luo et al--Impaired bronchoprotection in asthma.pdf
Journal Sections: 
Original Articles
Keywords: 
Alpha-actin
asthma
bronchoprotection
formoterol
Journal Authors: 
W Luo
C-T Liu
Q-H Yang
Q Yu
T Wang

Exploring the Reproductive Decision-making Process of HIV-positive Women in County Victoria, Trinidad and Tobago

Issue: 
Vol 1, Issue 3 (2014)
DOI: 
10.7727/wimjopen.2014.111
Pages: 
74–7
Synopsis: 
HIV-positive women enrolled in the Prevention of Mother to Child Transmission (PMTCT) programme in Trinidad and Tobago did not use family planning services, had unplanned pregnancies, and felt stigmatized when pregnant. Integrated treatment, family planning and PMTCT services can help HIV-positive women and their partners safely achieve their reproductive goals.

ABSTRACT

Received: 
May 19, 2014
Accepted: 
June 10, 2014
Published: 
September 30, 2014
PDF Attachment: 
PDF icon Joseph and Sharma--HIV and Reproductive decision-making.pdf
Journal Sections: 
Original Articles
Keywords: 
Caribbean
HIV positive women
repeat pregnancy
reproductive decision-making
Journal Authors: 
E Joseph
A Sharma

Impact of Undertreated Sickle Cell Pain in the Caribbean

Issue: 
Vol 1, Issue 2 (2014)
DOI: 
10.7727/wimjopen.2014.145
Synopsis: 
We surveyed adults with sickle cell disease (SCD) about their pain; results show that SCD pain in the Caribbean is undertreated and impacts negatively on education, employment, marital status and enjoyment of life.

ABSTRACT

Objective: Undertreated pain around the world includes the acute and chronic pain caused by sickle cell disease (SCD). In collaboration with a Caribbean association that aims to provide assistance to those diagnosed with SCD, we surveyed adults with SCD about pain management and impact of SCD pain.

Received: 
June 17, 2014
Accepted: 
June 30, 2014
PDF Attachment: 
PDF icon Shah et al--Impact of undertreated SCD.pdf
Journal Sections: 
Original Articles
Keywords: 
Caribbean
sickle cell disease
undertreated pain
Journal Authors: 
PD Shah
CC Macpherson
M Akpinar-Elci

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West Indian Medical Journal

Faculty of Medical Sciences,
The University of the West Indies,
Mona, Kingston 7
Tel: (876) 927-1214
Fax: (876) 927-1846
wimj@uwimona.edu.jm
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