Close Menu

D Ashe

Probing the Specifics of Substrate Binding for Cytochrome c Oxidase A Computer Assisted Approach

Issue: 
Pages: 
54–60
Synopsis: 
Transfer of electrons from ferrocytochrome C to cytochrome c oxidase is facilated by enzyme-substrate complexes stabilized by salt bridges. Computer simulations were employed to identify residues that participate in intermolecular salt bridges.

ABSTRACT

PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 17 Sep, 2013

Hydrogen/hydride Ion Relay – A Mechanism for Early Electron Transfer in Cytochrome c Oxidases

Issue: 
DOI: 
10.7727/wimj.2012.120
Pages: 
3–11
Synopsis: 
Cytochrome c oxidase (COX) employs electrons obtained from cytochrome c to reduce oxygen to water. Recently, we proposed that electrons travel from cytochrome c to CuA of COX, by a hydrogen/hydride ion relay. Now, on the basis of a similar computer study, we conclude that this hydride/hydrogen ion mechanism is common to other oxidases.

ABSTRACT

PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 09 Apr, 2013
Subscribe to RSS - D Ashe
Top of Page