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cytochrome c

Plasma Cellular Hypoxia, Mitochondrial Dysfunction, Disease Risk and Prognostic Factors in Type 2 Diabetic Patients in Saudi Arabia

Issue: 
DOI: 
10.7727/wimj.2017.117
Pages: 
262-73
Synopsis: 
This study investigated the level of plasma hypoxia-inducible factor (HIF)-1α and cytochrome c (CytoC) in correlation with C-reactive protein, dyslipidaemia, insulin resistance, and prognostic factors in Type 2 diabetic patients in Saudi Arabia. Reduced level of HIF-1α and non-significant increased level of CytoC correlated negatively with these prognostic factors. These results pointed to a possible pathogenetic implication for HIF-1α.

ABSTRACT

Objective: This cross-sectional study evaluated the association of plasma cytochrome c (CytoC) and hypoxia-inducible factor (HIF)-1α, as mitochondrial dysfunction and cellular hypoxia biomarkers, with disease risk factors and prognosis in Type 2 diabetic patients in Saudi Arabia.

Accepted: 
30 Jun, 2017
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Journal Sections: 
Journal Authors: 
e-Published: 21 Aug, 2017

Hydrogen/hydride Ion Relay – A Mechanism for Early Electron Transfer in Cytochrome c Oxidases

Issue: 
DOI: 
10.7727/wimj.2012.120
Pages: 
3–11
Synopsis: 
Cytochrome c oxidase (COX) employs electrons obtained from cytochrome c to reduce oxygen to water. Recently, we proposed that electrons travel from cytochrome c to CuA of COX, by a hydrogen/hydride ion relay. Now, on the basis of a similar computer study, we conclude that this hydride/hydrogen ion mechanism is common to other oxidases.

ABSTRACT

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e-Published: 09 Apr, 2013
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