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Efflux

Mutation and Efflux System are Responsible for Ciprofloxacin Resistance in Klebsiella pneumoniae

Issue: 
DOI: 
10.7727/wimj.2015.324
Pages: 
226-8
Synopsis: 
The results demonstrated that the main mechanism of ciprofloxacin resistance was via the AcrAB efflux system with a decrease of the level of minimal inhibitory concentration, but the other mechanism including mutation of gyrA and presence of quinolone resistance loci was also considerable.

ABSTRACT

Accepted: 
24 Aug, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 10 Mar, 2016

Meropenem Efflux in Pseudomonas aeruginosa at a Tertiary Care Hospital in Jamaica

Issue: 
DOI: 
10.7727/wimj.2016.022
Pages: 
105-9
Synopsis: 
This article examined efflux as a mechanism of carbapenem resistance in Pseudomonas aeruginosa isolates at a hospital in Jamaica. The study detected that 80% of the isolates tested had efflux as a mechanism of resistance to meropenem.

ABSTRACT

Objective: Several mechanisms account for carbapenem resistance in Pseudomonas (P.) aeruginosa which is an emerging problem at a tertiary care hospital (TCH) in Jamaica.  The observed pattern of carbapenem resistance that results from efflux mechanisms is unique because it is specific to meropenem (MEM).  Investigation of efflux as a mechanism of carbapenem resistance needed to be done as the information obtained could inform therapeutic and infection control strategies.

Accepted: 
21 Jan, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 01 Mar, 2016
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