The interferon-free regimens DAAs-based treatments have demonstrated the potential to cure HCV infection in adults with very high percentages and with good tolerability.
ABSTRACT
Objective: Was present a general overview of the current treatments for HCV infection in adults.
Methods: A review study was conducted, Databases such as PubMed, MEDLINE and Scopus were used as information sources to identify and analyze the current information about the treatment for HCV infection in adults
Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.
In this study, Mannose-Binding Lectin 2 (MBL2) gene polymorphism were investigated in patients with viral Hepatitis B and C. No significant differences in allele frequencies for any polymorphism were observed between patients and controls.
ABSTRACT
Objective: Mannose-binding lectin (MBL) has become a popular molecule in investigations on basic and clinical gastroenterology and contributed to new approaches to the understanding of infectious and immune diseases associated with intestine and liver. The aim of the present study was to investigate the association between codon 54 polymorphisms in MBL2 gene coding MBL and predisposition to fibrosis in patients with viral hepatitis B and C.
The study aimed at presenting a general overview of the current treatments for HCV infection in children. In children the most commonly used drugs are pegylated alpha interferon in combination with ribavirin only Boceprevir was tested and not approved for use in children. Safety and efficacy of new drugs in children need further investigation.
ABSTRACT
Background: HCV infection in children differs from infection in adult through transmission paths, spontaneous viral clearance rate, and fibrosis progression duration of chronic infection. It is estimated that the rate of children with chronic hepatitis C will develop cirrhosis is less than 2%, however there are reports of children requiring liver transplantation.
Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.
Chronic hepatitis C is a protective factor against having metabolic syndrome and this effect might be due to lower triglyceride level in the elderly. Further studies are warranted for the underlying mechanisms.
ABSTRACT
Background: In Taiwan, subjects over 65 years old have higher prevalence of hepatitis C. Among these patients, around 50% have non-alcoholic fatty liver disease (NAFLD). Since cardiovascular diseases and diabetes are main causes of death in this age group, in this cross-sectional study, we tried to evaluate the effects of NAFLD and hepatitis C on the risk of metabolic syndrome (MetS).