ABSTRACT

Background: Head and neck cancer patients treated with radiotherapy suffer severe side effects during and following their treatment. Efforts to decrease toxicity of irradiation to normal tissue, organs and cells have led to searching for cytoprotective agent. Investigations for effective and non-toxic compounds with radioprotective capability led to increasing interest in antioxidant such as Thymoquinone (TQ).

ABSTRACT

Objective: The aim of this study is to investigate the effects of addition of caffeic acid phenethyl ester (CAPE) and thymoquinone (TQ)on oxidative and nitrosative stress in the liver tissue of (IR) irradiated rats.

Methods: Forty Sprague-Dawley rats were divided into five groups to test the radioprotective effectiveness of TQand CAPE administered by intraperitoneal injection. Appropriate control groups were also studied.