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Newborn Screening for Sickle Cell Disease: Jamaican Experience

Issue: 
DOI: 
10.7727/wimj.2015.492
Pages: 
18–26
Synopsis: 
The history and evolution of laboratory technology for newborn screening for sickle cell disease is reviewed with particular reference to Jamaica. The procedures and results of screening 54 566 newborns from southern and western Jamaica are presented.

ABSTRACT

Objectives:  To review the history of newborn screening for sickle cell disease with especial reference to Jamaica.

Methods: A summary of the history, the development of associated laboratory technology and the implementation of newborn screening for sickle cell disease in Jamaica.

Accepted: 
22 Sep, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 22 Sep, 2015

Priapism in Homozygous Sickle Cell Disease: A 40-year Study of the Natural History

Issue: 
DOI: 
10.7727/wimj.2014.119
Pages: 
175–80
Synopsis: 
The authors report on the incidence, pattern, natural history and outcome of priapism in 162 male patients with homozygous sickle cell (SS) disease who have been followed from birth for periods up to 40 years.

 ABSTRACT

Objectives: To describe the incidence, pattern, and outcome of priapism in homozygous sickle cell (SS) disease.

Methods: Regular review, for periods up to 40 years was done, of all 162 males with SS disease detected during the screening of 100 000 consecutive non-operative deliveries at the main government maternity hospital in Kingston, Jamaica, between June 1973 and December 1981.

Revised: 
05 Jun, 2014
Accepted: 
05 Jun, 2014
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 27 Apr, 2015

Iron Deficiency among Jamaican Adolescents

Issue: 
DOI: 
10.7727/wimj.2013.240
Pages: 
561–5
Synopsis: 
Screening of 15 592 senior school students in the parish of Manchester, Jamaica, revealed that 3.8% of females had haemoglobin levels below 10 g/dL. Features were typical of iron deficiency and dramatic improvement followed iron supplementation. School medical examinations should include blood tests.

ABSTRACT

Objectives: To raise awareness of significant iron deficiency anaemia occurring in Jamaican secondary school students.

Methods: Haematological screening of students in the fifth and sixth forms of 14 secondary schools in the parishes of Manchester and Clarendon, Jamaica, was done. Samples were subject to haemoglobin electrophoresis, examination of haematological indices, and haemoglobin, alpha 2 (HbA2) levels where indicated.

Revised: 
09 Dec, 2013
Accepted: 
20 Jan, 2014
PDF Attachment: 
Journal Sections: 
e-Published: 26 Feb, 2015

Pattern of Pregnancy Weight Gain in Homozygous Sickle Cell Disease and effect on Birth Size

Issue: 
Pages: 
36–40
Synopsis: 
Maternal weight gain between 25–30 weeks gestation correlates positively with birthweight among AA mothers but appears delayed beyond 30 weeks in SS mothers.

ABSTRACT

Objective: To assess pregnancy weight gain and newborn anthropometry in mothers with homozygous sickle cell (SS) disease and normal controls.

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e-Published: 17 Oct, 2013

Homozygous Sickle Cell Disease in Uganda And Jamaica: A Comparison of Bantu and Benin Haplotypes

DOI: 
Doi:10.7727/wimj.2012.167

Objective: To compare the haematological and clinical features of homozygous sickle cell (SS) disease in Bantu and Benin haplotypes in a cross-sectional study of 115 Ugandan patients attending the Sickle Cell Clinic at Mulago Hospital, Kampala, Uganda, with 311 patients in the Jamaican Cohort Study.

Methods: This involved the comparison of clinical features and haematology with special reference to genetic determinants of severity including fetal haemoglobin levels, beta-globin haplotype, and alpha thalassaemia status.

PDF Attachment: 
Journal Sections: 
e-Published: 15 Feb, 2013

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

Homozygous Sickle Cell Disease in Uganda and Jamaica: A Comparison of Bantu and Benin Haplotypes

Issue: 
DOI: 
Doi:10.7727/wimj.2012.167
Pages: 
684–91
Synopsis: 
Comparison of the Bantu and Benin haplotypes in Ugandan and Jamaican patients with homozygous sickle cell disease reveal some clinical and haemato-logical differences. Better documentation is needed to derive optimal models of care for Ugandan patients.

ABSTRACT

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Journal Sections: 
e-Published: 01 Mar, 2013
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