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Original Articles

Effect of Metformin on Miscarriage in Pregnant Patients with Polycystic Ovary Syndrome

Issue: 
Pages: 
433–6
Synopsis: 
In pregnant patients with polycystic ovary syndrome, continuing metformin until 8-12 weeks gestation seems to be effective in preventing miscarriage without proven teratogenic effects.

ABSTRACT

Background: This study was performed with the aim of evaluating the effect of metformin in reducing miscarriage when continued until the end of the first trimester of pregnancy in patients with polycystic ovary syndrome (PCOS) and infertility.

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e-Published: 20 Sep, 2013

Does Helicobacter Pylori Identification in the Mucosa of the Gallbladder Correlate to Cholesterol Gallstone Formation?

Issue: 
Pages: 
428–32
Synopsis: 
Using both standard histology and polymerase chain reaction, H pylori was detectable in a low frequency in the mucosa of the gallbladder and no statistical differences were found between patients with cholesterol gallstones and patients without cholelithiasis. Thus, H pylori does not seem to act as a lithogenic component for cholesterol gallstone formation.

ABSTRACT

Objective: Helicobacter pylori (H pylori) represents a potential initiator of cholesterol crystallization and it has been proposed that it is related to gallstone formation. In this study, any possible association between the H pylori identification in the mucosa of gallbladder and cholesterol gallstone formation was evaluated.

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e-Published: 20 Sep, 2013

The Effects of Ingested Aluminium on Brain Cytochrome Oxidase Activity

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Pages: 
422–7
Synopsis: 
When rabbits were maintained on a diet supplemented with aluminium, a 35% decrease in brain cytochrome c oxidase activity (COX) was observed. Isolation of number of the enzyme’s low molecular weight subunits was absent.

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e-Published: 20 Sep, 2013

Soluble Cell Adhesion Molecules and Parameters of Lipoprotein Metabolism in Patients with Severe Burns

Issue: 
Pages: 
417–21
Synopsis: 
The observed inflammatory response of soluble cell adhesion molecules could be useful in monitoring endothelial activation immediately following thermal injury.

ABSTRACT

Background: The role of leukocyte adhesion molecules in patients with burns and their relationship to other parameters of inflammation and lipid metabolism is only recently beginning to be explored. Therefore, we investigated the temporal changes in the levels of soluble cell adhesion molecules and other parameters of inflammation and lipoprotein metabolism in patients with thermal injury.

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e-Published: 20 Sep, 2013

Effect of Acute Changes in Glucose Concentration on Neuronal Activity and Plasticity in the Rat Hippocampus

Issue: 
Pages: 
410–6
Synopsis: 
Acute changes in glucose concentration have a limited impact on neuronal transmission unless concentrations drop below 2mM. However, there seems to be little impairment of synaptic plasticity even at very low concentrations of glucose.

ABSTRACT

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e-Published: 20 Sep, 2013

Implications of Dibenzyl Trisulphide for Disease Treatment Based on its Mode of Action

Issue: 
Pages: 
407–9
Synopsis: 
The MAPKinase signal transduction biochemical pathways are important in the regulation of a wide range of cellular processes which are important in disease establishment.

ABSTRACT

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e-Published: 20 Sep, 2013

Prescribing Medications and Nutritional Supplements for Athletes

Issue: 
Pages: 
352–6
Synopsis: 
This is a brief overview of the banned or restricted classes of substances in sport.

ABSTRACT

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e-Published: 19 Sep, 2013

Hirschsprung’s Disease in Barbados: A 16-year Review

Issue: 
Pages: 
347–51
Synopsis: 
The referral patterns to one of the centres in the Caribbean offering definitive surgery for Hirschsprung’s disease is outlined and the surgical outcome reported. Factors responsible for the lack of use of more advanced surgical techniques are discussed as well as factors that may contribute to earlier diagnosis.

ABSTRACT

Objective: To assess the surgical outcome of patients with Hirschsprung’s disease (HD) who were treated in Barbados, establish referral patterns and identify factors which can lead to better management.

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e-Published: 19 Sep, 2013

Delays in Presentations of Stroke Patients at the University Hospital of the West Indies

Issue: 
Pages: 
341–6
Synopsis: 
Early diagnosis of patients with stroke is paramount in order to achieve benefits from thrombolytic therapy. Public education, improved access to pre-hospital care and healthcare personnel along with prompt neuroimaging are some means by which care can be improved.

ABSTRACT

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e-Published: 19 Sep, 2013

Preliminary Report on the Validation of a Questionnaire Measuring Patient Satisfaction with Services at the Sickle Cell Unit in Jamaica

Issue: 
Pages: 
331–40
Synopsis: 
Patient satisfaction has become an increasingly important component of quality assessment. This paper assessed the psychometric properties of a Patient Satisfaction Questionnaire modified for use in the Sickle Cell Unit, Jamaica.

ABSTRACT

Objective: Patient satisfaction has become an increasingly important component of quality assessment. This cross-sectional study was conducted to assess the psychometric properties of a Patient Satisfaction Questionnaire modified for use in the Sickle Cell Unit, Jamaica.

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e-Published: 19 Sep, 2013

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